Chronic Pain Suicidal Behavior from Prescription Drugs

Suicidal Behavior and Ideation and Antiepileptic Drugs

Karen was taking this crap, Gabapentin (Neurontin) that is on this list. These are commonly given to people with Chronic Pain, whom are already usually depressed.

Manufacturers of antiepileptic drugs (AEDs) or anticonvulsant drugs will update product labeling to include a warning about an increased risk of suicidal thoughts or actions and will develop a Medication Guide to help patients understand this risk.

This is the actual study frequently referenced to on Internet with no link to the original study as “Neurontin and Lyrica are a Death Sentence for New Brain Synapses”: Study pinpoints key mechanism in brain development, raising questions about use of antiseizure drug

Gabapentin Receptor α2δ-1 Is a Neuronal Thrombospondin Receptor Responsible for Excitatory CNS Synaptogenesis

Çagla Eroglu, Nicola J. Allen, Michael W. Susman, Nancy A. O'Rourke, Chan Young Park, Engin Özkan, Chandrani Chakraborty, Sara B. Mulinyawe, Douglas S. Annis, Andrew D. Huberman, Eric M. Green, Jack Lawler, Ricardo Dolmetsch, K. Christopher Garcia, Stephen J. Smith, Z. David Luo, Arnon Rosenthal, Deane F. Mosher, Ben A. Barres

Synapses are asymmetric cellular adhesions that are critical for nervous system development and function, but the mechanisms that induce their formation are not well understood. We have previously identified thrombospondin as an astrocyte-secreted protein that promotes central nervous system (CNS) synaptogenesis. Here, we identify the neuronal thrombospondin receptor involved in CNS synapse formation as α2δ-1, the receptor for the anti-epileptic and analgesic drug gabapentin. We show that the VWF-A domain of α2δ-1 interacts with the epidermal growth factor-like repeats common to all thrombospondins. – In Cell Oct 16 2009.

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